CHEMICAL IDENTIFICATION
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  RTECS NUMBER :
 
 
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  GV2800000
 
 
 
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  CHEMICAL NAME :
 
 
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  Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester, hydrochloride
 
 
 
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  CAS REGISTRY NUMBER :
 
 
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  1508-65-2
 
 
 
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  LAST UPDATED :
 
 
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  199504
 
 
 
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  DATA ITEMS CITED :
 
 
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  15
 
 
 
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  MOLECULAR FORMULA :
 
 
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  C22-H31-N-O3.Cl-H
 
 
 
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  MOLECULAR WEIGHT :
 
 
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  394.00
 
 
 
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  WISWESSER LINE NOTATION :
 
 
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  L6TJ AXQR&VO2UU2N2&2 &GH
 
 
 
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
 - 
  TYPE OF TEST :
 
 
 - 
  Standard Draize test
 
 
 
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  ROUTE OF EXPOSURE :
 
 
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  Administration into the eye
 
 
 
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  SPECIES OBSERVED :
 
 
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  Rodent - rabbit
 
 
 
 - 
  REFERENCE :
 
 
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  OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 27,931,1984 ** ACUTE TOXICITY DATA **
 
 
 
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  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Human - woman
 
 
 
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  DOSE/DURATION :
 
 
 - 
  2 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Cardiac - change in rate Behavioral - coma
 
 
 
 - 
  REFERENCE :
 
 
 - 
  HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 10,225,1991
 
 
 
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  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
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  DOSE/DURATION :
 
 
 - 
  460 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988
 
 
 
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  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
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  DOSE/DURATION :
 
 
 - 
  223 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988
 
 
 
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  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
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  DOSE/DURATION :
 
 
 - 
  740 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988
 
 
 
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  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
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  DOSE/DURATION :
 
 
 - 
  61 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  725 mg/kg
 
 
 
 - 
  TOXIC EFFECTS :
 
 
 - 
  Autonomic Nervous System - parasympatholytic
 
 
 
 - 
  REFERENCE :
 
 
 - 
  AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 156,467,1965
 
 
 
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  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intraperitoneal
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  185 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Autonomic Nervous System - parasympatholytic
 
 
 
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  REFERENCE :
 
 
 - 
  AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 156,467,1965
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Subcutaneous
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
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  DOSE/DURATION :
 
 
 - 
  2225 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Intravenous
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - mouse
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  42 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#11090
 
 
 
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  TYPE OF TEST :
 
 
 - 
  LD50 - Lethal dose, 50 percent kill
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
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  SPECIES OBSERVED :
 
 
 - 
  Mammal - dog
 
 
 
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  DOSE/DURATION :
 
 
 - 
  >400 mg/kg
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Details of toxic effects not reported other than lethal dose value
 
 
 
 - 
  REFERENCE :
 
 
 - 
  AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 156,467,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  SPECIES OBSERVED :
 
 
 - 
  Rodent - rat
 
 
 
 - 
  DOSE/DURATION :
 
 
 - 
  2100 mg/kg/15W-C
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Lungs, Thorax, or Respiration - other changes Endocrine - adrenal cortex hyperplasia Blood - changes in spleen
 
 
 
 - 
  REFERENCE :
 
 
 - 
  KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,449,1985 ** REPRODUCTIVE DATA **
 
 
 
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  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
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  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
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  DOSE :
 
 
 - 
  1100 mg/kg
 
 
 
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  SEX/DURATION :
 
 
 - 
  female 7-17 day(s) after conception
 
 
 
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  TOXIC EFFECTS :
 
 
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  Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 40,31,1986
 
 
 
 - 
  TYPE OF TEST :
 
 
 - 
  TDLo - Lowest published toxic dose
 
 
 
 - 
  ROUTE OF EXPOSURE :
 
 
 - 
  Oral
 
 
 
 - 
  DOSE :
 
 
 - 
  1350 mg/kg
 
 
 
 - 
  SEX/DURATION :
 
 
 - 
  female 17-22 day(s) after conception lactating female 21 day(s) post-birth
 
 
 
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  TOXIC EFFECTS :
 
 
 - 
  Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
 
 
 
 - 
  REFERENCE :
 
 
 - 
  TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 40,31,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6170 No. of Facilities: 63 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2249 (estimated) No. of Female Employees: 1132 (estimated)
 
 
  
                                        
                                     
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