perospirone
Modify Date: 2024-01-02 01:33:13
perospirone structure
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Common Name | perospirone | ||
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| CAS Number | 150915-41-6 | Molecular Weight | 440.602 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 648.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C23H30N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 346.2±34.3 °C | |
Use of perospironePerospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic drug and has the potential for schizophrenic disease[1][2]. |
| Name | (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione |
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| Synonym | More Synonyms |
| Description | Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic drug and has the potential for schizophrenic disease[1][2]. |
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| Related Catalog | |
| Target |
5-HT2A Receptor:0.6 nM (Ki) Dopamine D2:1.4 nM (Ki) 5-HT1A Receptor:2.9 nM (Ki) 5-HT1 Receptor:18 nM (Ki) Dopamine D1:41 nM (Ki) |
| In Vitro | Perospirone (SM-9018 free base) possesses moderate affinities for α1, 5-HT1, and D1 receptors (Ki=17, 18 and 41 nM, respectively) [1]. |
| In Vivo | Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner[2]. Animal Model: Male ICR mice (6 weeks old) weighing 25-30 g[2] Dosage: 1.0, 3.0 or 10.0 mg/kg Administration: Orally; daily; for 14 consecutive days Result: Significantly attenuated PCP-induced cognitive deficits in mice in a dose-dependent manner. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.8±65.0 °C at 760 mmHg |
| Molecular Formula | C23H30N4O2S |
| Molecular Weight | 440.602 |
| Flash Point | 346.2±34.3 °C |
| Exact Mass | 440.224609 |
| PSA | 84.99000 |
| LogP | 1.85 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.702 |
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~%
perospirone CAS#:150915-41-6 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 43, # 12 p. 2139 - 2151 |
| Precursor 1 | |
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| DownStream 0 | |
| (3aR,7aS)-2-{4-[4-(1H-2,3-Benzothiazin-4-yl)piperazin-1-yl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione |
| cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide |
| Lullan |
| (3aR,7aS)-2-{4-[4-(1H-2,3-Benzothiazin-4-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione |
| 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1H-2,3-benzothiazin-4-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)- |
| Perospirone |
| M813 |
| UNII-N303OK87DT |