antarelix

Modify Date: 2024-01-13 12:20:07

antarelix structure	Common Name	antarelix
	CAS Number	151272-78-5	Molecular Weight	1459.131
	Density	1.3±0.1 g/cm3	Boiling Point	1692.9±65.0 °C at 760 mmHg
	Molecular Formula	C₇₄H₁₀₀ClN₁₅O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	977.6±34.3 °C

Use of antarelix

Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer[1][2].

Name	teverelix
Synonym	More Synonyms

Description	Teverelix (EP 24332) is a GnRH antagonist. Teverelix binds competitively and reversibly to GnRH receptors, thereby suppressing the release of LH and FSH. Teverelix can be used in the research of prostatic hyperplasia, endometriosis, and prostate cancer[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Teverelix (10 nM, 45 mins) inhibits GnRH-induced intracellular Ca2+ increase in HEK293/GnRHR cells[2]. Teverelix (0.1 nM-1 μM, 45 mins) inhibits GnRH-induced cAMP accumulation in HEK293/GnRHR cells[2]. Teverelix (10 nM-1 μM, 15 mins) inhibits GnRH-induced pERK1/2 and pCREB activation in HEK293/GnRHR cells[2]. Teverelix inhibits histamine release in a peritoneal rat mast cell, with an EC50value of 81 μg/mL[3]. Western Blot Analysis[2] Cell Line: HEK293/GnRHR cells Concentration: 10 nM, 100 nM, 1 μM Incubation Time: 15 mins Result: Inhibited GnRH-induced pERK1/2 and pCREB activation.
In Vivo	Teverelix (3-300 μg/kg, intramuscular injection) inhibits testosterone in rats[3]. Teverelix (1 mg/kg, s.c, daily for 3 days) abolishes luteal function in stumptailed macaques[4]. Animal Model: Rats[3] Dosage: 300, 100, 30, 10 and 3 μg/kg Administration: Intramuscular injection Result: Showed dose-response and time-course of testosterone inhibitory activity.

Density	1.3±0.1 g/cm3
Boiling Point	1692.9±65.0 °C at 760 mmHg
Molecular Formula	C₇₄H₁₀₀ClN₁₅O₁₄
Molecular Weight	1459.131
Flash Point	977.6±34.3 °C
Exact Mass	1457.726318
LogP	4.49
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.597

7079

D19V7048JK

N-Acetyl-3-(2-naphthyl)-D-alanyl-p-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N6-carbamoyl-D-lysyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide

(2S)-N-[(2R)-1-Amino-1-oxo-2-propanyl]-1-[(2S,5S,8R,11S,14S,17R,20R,23R)-8-[4-(carbamoylamino)butyl]-20-(4-chlorobenzyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-2-[4-(isopropylamino)butyl]-23-(2-naphthylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(3-pyridinylmethyl)-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl]-2-pyrrolidinecarboxamide

teverelix

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: teverelix
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Tom
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Teverelix
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Lai
Email: order@dcbio.cn

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: antarelix
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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