rac-Acolbifene
Modify Date: 2024-01-12 11:39:35
rac-Acolbifene structure
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Common Name | rac-Acolbifene | ||
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| CAS Number | 151533-34-5 | Molecular Weight | 457.56100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H31NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of rac-Acolbifene(Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380[1]. |
| Name | 2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-methyl-7-hydroxy-2H-1-benzopyran |
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| Synonym | More Synonyms |
| Description | (Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380[1]. |
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| Related Catalog | |
| In Vitro | (Rac)-Acolbifene (EM-343; (Rac)-EM-652) shows a inhibitory effect in T-47D cells with an IC50 value of 0.110 nM[1]. Cell Viability Assay[1] Cell Line: T-47D cells Concentration: 0.110 nM Incubation Time: 72 hours Result: Inhibited T-47D cells growth. |
| In Vivo | (Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice)[1]. |
| References |
| Molecular Formula | C29H31NO4 |
|---|---|
| Molecular Weight | 457.56100 |
| Exact Mass | 457.22500 |
| PSA | 62.16000 |
| LogP | 5.96480 |
| Precursor 0 | |
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| DownStream 1 | |
CAS#:182167-02-8| 7-hydroxy-3-(4'-hydroxyphenyl)-4-methyl-2-(4"-(2"'-piperidinoethoxy)phenyl)-2H-benzopyran |
| rac-Acolbifene |
| 2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl) -4-methyl-7-hydroxy-2H-1-benzopyran |