Afabicin

Modify Date: 2024-01-08 19:45:53

Afabicin structure	Common Name	Afabicin
	CAS Number	1518800-35-5	Molecular Weight	485.426
	Density	1.4±0.1 g/cm3	Boiling Point	876.6±75.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₄N₃O₇P	Melting Point	N/A
	MSDS	N/A	Flash Point	483.9±37.1 °C

Use of Afabicin

Afabicin is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

Name	afabicin
Synonym	More Synonyms

Description	Afabicin is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
Target	FabI, Bacterial[1]
In Vitro	Afabicin (Debio1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively. Debio1452 also inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively[1].
References	[1]. Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015 May;59(5):2583-7.

Density	1.4±0.1 g/cm3
Boiling Point	876.6±75.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₄N₃O₇P
Molecular Weight	485.426
Flash Point	483.9±37.1 °C
Exact Mass	485.135193
LogP	0.87
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.667

{6-[(1E)-3-{Methyl[(3-methyl-1-benzofuran-2-yl)methyl]amino}-3-oxo-1-propen-1-yl]-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl}methyl dihydrogen phosphate

2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-[5,6,7,8-tetrahydro-7-oxo-8-[(phosphonooxy)methyl]-1,8-naphthyridin-3-yl]-, (2E)-

afabicin

DMM8663H2R

Afabicin

Use of Afabicin

Names

Afabicin Biological Activity

Chemical & Physical Properties

Synonyms