Prezalumab

Modify Date: 2025-08-26 08:11:40

Prezalumab Structure
Prezalumab structure
Common Name Prezalumab
CAS Number 1523164-68-2 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Prezalumab


Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1].

 Names

Name Prezalumab

 Prezalumab Biological Activity

Description Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE)[1].
Related Catalog
In Vivo 在小鼠 NZB/NZW 狼疮模型和胶原性关节炎 (CIA) 模型中,Prezalumab 比单一 ICOSL 或 BAFF 抑制剂更有效[1]。 Prezalumab 减少食蟹猴的 B 细胞,其药理作用与 BAFF 抑制剂相同[1]。
References

[1]. Zhang M, et al. Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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