AB-MECA

Modify Date: 2025-08-31 20:21:30

AB-MECA Structure
AB-MECA structure
Common Name AB-MECA
CAS Number 152918-26-8 Molecular Weight 399.40400
Density 1.68g/cm3 Boiling Point N/A
Molecular Formula C18H21N7O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of AB-MECA


AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.

 Names

Name (2S,3S,4R,5R)-5-[6-[(4-aminophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Synonym More Synonyms

 AB-MECA Biological Activity

Description AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.
Related Catalog
References

[1]. Shearman LP, et al. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptorsubtypes in rat brain. Brain Res. 1997 Jan 16;745(1-2):10-20.

 Chemical & Physical Properties

Density 1.68g/cm3
Molecular Formula C18H21N7O4
Molecular Weight 399.40400
Exact Mass 399.16600
PSA 163.93000
LogP 0.88030
Index of Refraction 1.789
Storage condition 2-8℃

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles3

More Articles
125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

Mol. Pharmacol. 45 , 978-982, (1994)

The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, a high affinity A1AR agonist, ha...

A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

FEBS Lett. 336 , 57-60, (1993)

The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse bra...

Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.

J. Med. Chem. 37 , 636-646, (1994)

Adenosine analogues modified at the 5'-position as uronamides and/or as N6-benzyl derivatives were synthesized. These derivatives were examined for affinity in radioligand binding assays at the newly ...

 Synonyms

N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine
[3H]AB-MECA
AB-MECA
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