Glycolithocholic acid 3-sulfate

Modify Date: 2024-01-03 12:27:52

Glycolithocholic acid 3-sulfate structure	Common Name	Glycolithocholic acid 3-sulfate
	CAS Number	15324-64-8	Molecular Weight	512.67900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₄₂NO₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Glycolithocholic acid 3-sulfate

Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease[1][2].

Name	sulfoglycolithocholic acid
Synonym	More Synonyms

Description	Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	Microbial Metabolite
In Vitro	Glycolithocholic acid 3-sulfate (100 μg/mL) 可保护 MT-4 细胞免受 HIV-1 诱导的细胞病变[1]。 Glycolithocholic acid 3-sulfate (200 μg/mL) 对宿主细胞无毒性[1]。 Glycolithocholic acid 3-sulfate 抑制 HIV-1 感染的 CEM 细胞中 HIV-1 抗原的表达[1]。
In Vivo	Glycolithocholic acid 3-sulfate (24 μmoL/100 g；静脉注射，1 次) 诱导胆瘘的雄性 Wistar 大鼠肝内胆汁淤积，增加胆汁胆固醇分泌[2]。 Animal Model: Male Wistar rats with bile fistula[2] Dosage: 24 μmoL/100 g Administration: Intravenous injection; 24 μmoL/100 g Result: Induced intrahepatic cholestasis and increased biliary cholesterol secretion.
References	[1]. Baba M, et al. Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. J Acquir Immune Defic Syndr (1988). 1989;2(3):264-71. [2]. Yousef IM,et al. Lithocholate cholestasis--sulfated glycolithocholate-induced intrahepatic cholestasis in rats. Gastroenterology. 1981 Feb;80(2):233-41.

Molecular Formula	C₂₆H₄₂NO₇S
Molecular Weight	512.67900
Exact Mass	512.26800
PSA	144.70000
LogP	6.24400

Glycolithocholate 3-sulfate

Sulfolithocholylglycine

N-(3alpha-hydroxy-5beta-cholan-24-oyl)-glycine 3-sulfate

Sulfoglycolithocholate

[(3R,5R,8R,9S,10S,13R,14S,17R)-17-[(2R)-5-(carboxymethylamino)-5-oxopentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate

Glycolithocholic acid 3-sulfate

Use of Glycolithocholic acid 3-sulfate

Names

Glycolithocholic acid 3-sulfate Biological Activity

Chemical & Physical Properties

Synonyms