5'-O-DMT-N4-Bz-2'-ara-F-2'-dC

Modify Date: 2024-05-02 10:03:37

5'-O-DMT-N4-Bz-2'-ara-F-2'-dC Structure
5'-O-DMT-N4-Bz-2'-ara-F-2'-dC structure
Common Name 5'-O-DMT-N4-Bz-2'-ara-F-2'-dC
CAS Number 154771-33-2 Molecular Weight 651.68
Density 1.30g/cm3 Boiling Point N/A
Molecular Formula C37H34FN3O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5'-O-DMT-N4-Bz-2'-ara-F-2'-dC


DMT-2'-F-Bz-dC is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

 Names

Name N-[1-[(2R,3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
Synonym More Synonyms

 5'-O-DMT-N4-Bz-2'-ara-F-2'-dC Biological Activity

Description DMT-2'-F-Bz-dC is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Related Catalog
References

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

 Chemical & Physical Properties

Density 1.30g/cm3
Molecular Formula C37H34FN3O7
Molecular Weight 651.68
Exact Mass 651.23800
PSA 121.14000
LogP 5.19090
Index of Refraction 1.621

 Synonyms

DMT-2'-F-Bz-dC
N-[1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide
N-(1-((2R,3S,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
5'-O-DMT-N4-Bz-2'-ara-F-2'-dC