Avitinib

Modify Date: 2024-01-11 16:46:17

Avitinib structure	Common Name	Avitinib
	CAS Number	1557267-42-1	Molecular Weight	487.529
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₆FN₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Avitinib

Avitinib (AC0010) is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR T790M resistance mutations in non-small cell lung cancer (NSCLC). Abivertinib is also a novel BTK inhibitor.

Name	N-{3-[(2-{[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}acrylamide
Synonym	More Synonyms

Description	Avitinib (AC0010) is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR T790M resistance mutations in non-small cell lung cancer (NSCLC). Abivertinib is also a novel BTK inhibitor.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
References	[1]. Xu X, Mao L, Xu W, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016;15(11):2586-2597. [2]. Yan X, Zhou Y, Huang S, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

References

[1]. Xu X, Mao L, Xu W, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016;15(11):2586-2597.

[2]. Yan X, Zhou Y, Huang S, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706.

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₆H₂₆FN₇O₂
Molecular Weight	487.529
Exact Mass	487.213196
LogP	3.50
Index of Refraction	1.697
Storage condition	-20℃

N-{3-[(2-{[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}acrylamide

2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-

Avitinib

Avi Tini

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Avitinib
Price: ￥10036.0/1g ￥1256.0/25mg ￥626.0/5mg ￥2516.0/100mg
Purity: 97.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Avitinib free base
Price: $450.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Avitinib suppliers

Avitinib price

Avitinib

Use of Avitinib

Names

Avitinib Biological Activity

Chemical & Physical Properties

Synonyms