Nickel ammonium sulfate

EMERGENCY OVERVIEW
Harmful if swallowed. Possible risks of irreversible effects. May cause sensitization by inhalation and skin contact.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Dust is irritating to the respiratory tract. May cause allergic respiratory reaction.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately.
Skin:
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Substance is noncombustible; use agent most appropriate to extinguish surrounding fire.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, observing precautions in the Protective Equipment section.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Use only in a well ventilated area. Avoid contact with skin and eyes. Do not ingest or inhale.
Storage:
Store in a cool, dry place. Keep container closed when not in use.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Local exhaust ventilation may be necessary to control any air contaminants to within their TLVs during the use of this product.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Appearance: green
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Decomposition Temperature: Not available.
Solubility: Soluble in hot water.
Specific Gravity/Density: Not available.
Molecular Formula: O8S2Ni.2H4N
Molecular Weight: 286.8746

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Oxides of nitrogen, oxides of sulfur, nickel oxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 15699-18-0: WS6050000 LD50/LC50:
CAS# 15699-18-0: Oral, rat: LD50 = 400 mg/kg.
Carcinogenicity:
Nickel ammonium sulfate - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION
For further information, contact Fisher Scientific.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

CDG/CPL
IMO
No information available.
IATA
No information available.
RID/ADR
No information available.
Canadian TDG
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 40 Possible risks of irreversible effects.
R 42/43 May cause sensitization by inhalation and
skin contact.
Safety Phrases:
S 22 Do not inhale dust.
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 15699-18-0:
Canada
CAS# 15699-18-0 is listed on Canada's DSL/NDSL List.
WHMIS: Not available.
CAS# 15699-18-0 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 15699-18-0:. OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3. OEL-A
USTRALIA:TWA 1 mg(Ni)/m3. OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compo
unds). OEL-BELGIUM:TWA 1 mg(Ni)/m3. OEL-CZECHOSLOVAKIA:TWA 0.05 mg(Ni)
/m3;STEL 0.25 mg(Ni)/m3. OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen. OE
L-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds). OEL-FINLAND:TWA 0.1 m
g(Ni)/m3;Carcinogen. OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;CAR (insoluble
compounds). OEL-FRANCE:TWA 1 mg(Ni)/m3. OEL-GERMANY;Carcinogen
UNGARY:STEL 0.005 mg(Ni)/m3;CAR (insoluble compounds). OEL-HUNGARY:STE
L 0.005 mg(Ni)/m3;Carcinogen. OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen. OE
L-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3. OEL-THE NETHERLANDS:TWA 1 mg(Ni)/
m3 (insoluble compounds). OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3. OEL-RUS
SIA:STEL 0.05 mg(Ni)/m3. OEL-SWEDEN:TWA 0.5 mg(Ni)/m3. OEL-SWITZERLAND
:TWA 0.5 mg(Ni)/m3 (insoluble compounds). OEL-SWITZERLAND:TWA 0.5 mg(N
i)/m3;Carcinogen JAN9. OEL-THAILAND:TWA 1 mg(Ni)/m3. OEL-UNITED KINGDO
M:TWA 0.5 mg(Ni)/m3 (insoluble compounds). OEL-UNITED KINGDOM:TWA 1 mg
(Ni)/m3
IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 15699-18-0 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

MOLECULAR WEIGHT :

286.93

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FDRLI* Food & Drug Research Laboratories, Inc., Papers. (P.O. Box 107, Rt. 17C, Waverly, NY 14892-0107) Volume(issue)/page/year: 8005A,1984

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

68100 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 23,153,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

19600 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 23,153,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

926 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 23,153,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

68100 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 23,153,1991

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

43 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 23,153,1991 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 49,257,1990 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 mg(Ni)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,178,1971 OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993 OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993 OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen JAN 1993 OEL-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN 1993 OEL-FRANCE:TWA 1 mg(Ni)/m3 JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN 1993 OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993 OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993 OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4948 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated)