L-159282 structure
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Common Name | L-159282 | ||
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CAS Number | 157263-00-8 | Molecular Weight | 524.63300 | |
Density | 1.27g/cm3 | Boiling Point | N/A | |
Molecular Formula | C30H28N4O3S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of L-159282L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. |
Name | N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]phenyl]sulfonylbenzamide |
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Synonym | More Synonyms |
Description | L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. |
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Related Catalog | |
In Vivo | In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1]. |
References |
Density | 1.27g/cm3 |
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Molecular Formula | C30H28N4O3S |
Molecular Weight | 524.63300 |
Exact Mass | 524.18800 |
PSA | 105.82000 |
LogP | 7.10010 |
Index of Refraction | 1.654 |
Storage condition | 2-8℃ |
mk-996 |
L-159282 |