Catalpalactone

Modify Date: 2024-01-10 10:21:00

Catalpalactone structure	Common Name	Catalpalactone
	CAS Number	1585-68-8	Molecular Weight	258.269
	Density	1.3±0.1 g/cm3	Boiling Point	467.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	245.2±27.1 °C

Use of Catalpalactone

Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2].

Name	3-(2,2-dimethyl-6-oxo-3H-pyran-5-yl)-3H-2-benzofuran-1-one
Synonym	More Synonyms

Description	Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236. [2]. Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91.

Description

Related Catalog

Research Areas >> Inflammation/Immunology

References

[1]. Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236.

[2]. Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91.

Density	1.3±0.1 g/cm3
Boiling Point	467.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄O₄
Molecular Weight	258.269
Flash Point	245.2±27.1 °C
Exact Mass	258.089203
PSA	52.60000
LogP	2.05
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.576

Precursor 9
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