CMF-019

Modify Date: 2025-08-24 21:39:12

CMF-019 Structure
CMF-019 structure
 Common Name CMF-019
CAS Number 1586787-08-7 Molecular Weight 455.61
Density N/A Boiling Point N/A
Molecular Formula C25H33N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CMF-019


CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents[1]. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin[2].

 Names

Name CMF019

 CMF-019 Biological Activity

Description CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents[1]. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin[2].
Related Catalog
Target

pKi: 8.58 (human Apelin receptor) ; 8.49 (rat Apelin receptor); 8.71 (mouse Apelin receptor)[1].

References

[1]. Trifonov L, et al. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018;14(7):688-694.

[2]. Read C, et al. Cardiac action of the first G protein biased small molecule apelin agonist. Biochem Pharmacol. 2016 Sep 15;116:63-72.

 Chemical & Physical Properties

Molecular Formula C25H33N3O3S
Molecular Weight 455.61
Storage condition -20°C
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Chemsrc provides CMF-019(CAS#:1586787-08-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of CMF-019 are included as well.>> amp version: CMF-019

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