IQS-019
Modify Date: 2025-10-22 19:11:46
IQS-019 structure
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Common Name | IQS-019 | ||
|---|---|---|---|---|
| CAS Number | 1630804-24-8 | Molecular Weight | 510.423 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25Cl2N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IQS-019A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively; inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs; impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib. |
| Name | IQS-019 |
|---|
| Description | A novel, potent inhibitor of most upstream tyrosine kinases in BCR signaling pathway, inhibits BCR kinases Lyn, Syk and Btk with IC50 of 0.15 uM, 1.6 uM and 2.1 uM, respectively; inhibits at least 20% of the kinase activity at 0.1 uM) and an almost complete kinase inactivation at the 10 uM in a set of 17 TK/TKLs; impaires cell proliferation, reduces CXCL12-dependent cell migration, and induces caspase-dependent apoptosis; shows improved efficacy in vitro and in vivo compared to ibrutinib. |
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| References | References 1. Balsas P, et al. J Hematol Oncol. 2017 Mar 31;10(1):80. 2. Puig de la Bellacasa R, et al. Eur J Med Chem. 2014 Oct 30;86:664-75. View Related Products by Target BTK |
| Molecular Formula | C25H25Cl2N7O |
|---|---|
| Molecular Weight | 510.423 |