Phe-Met-Arg-Phe amide trifluoroacetate

Modify Date: 2024-01-31 20:24:26

Phe-Met-Arg-Phe amide trifluoroacetate structure	Common Name	Phe-Met-Arg-Phe amide trifluoroacetate
	CAS Number	159237-99-7	Molecular Weight	826.81
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₄F₆N₈O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Phe-Met-Arg-Phe amide trifluoroacetate

Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons.

Name	Phe-Met-Arg-Phe amide trifluoroacetate

Description	Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Neurological Disease Peptides
Target	ED50: 23 nM (K+ current)[1]
In Vitro	In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels[1]. Phe-Met-Arg-Phe amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2].
In Vivo	Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min[3].
References	[1]. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. [2]. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. [3]. Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7.

Molecular Formula	C₃₃H₄₄F₆N₈O₈S
Molecular Weight	826.81
Storage condition	-20°C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phe-Met-Arg-Pheamidetrifluoroacetate
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: Phe-Met-Arg-Phe amide trifluoroacetate
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

Get all suppliers and price by the below link:

Phe-Met-Arg-Phe amide trifluoroacetate suppliers

Price: $131/10mM*1mLinWater

Reference only. check more Phe-Met-Arg-Phe amide trifluoroacetate price