Z-Gly-Pro-Phe-Leu-CHO

Modify Date: 2024-01-12 14:03:41

Z-Gly-Pro-Phe-Leu-CHO structure	Common Name	Z-Gly-Pro-Phe-Leu-CHO
	CAS Number	159659-05-9	Molecular Weight	550.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₈N₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Z-Gly-Pro-Phe-Leu-CHO

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].

Name	Z-Gly-Pro-Phe-Leu-CHO

Description	Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53.

Molecular Formula	C₃₀H₃₈N₄O₆
Molecular Weight	550.65

Z-Gly-Pro-Phe-Leu-CHO

Use of Z-Gly-Pro-Phe-Leu-CHO

Names

Z-Gly-Pro-Phe-Leu-CHO Biological Activity

Chemical & Physical Properties