(Rac)-BRD0705
Modify Date: 2024-01-13 16:37:28
(Rac)-BRD0705 structure
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Common Name | (Rac)-BRD0705 | ||
|---|---|---|---|---|
| CAS Number | 1597440-03-3 | Molecular Weight | 321.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H23N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Rac)-BRD0705(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2]. |
| Name | (Rac)-BRD0705 |
|---|
| Description | (Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2]. |
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| Related Catalog | |
| References |
[2]. Edward Scolnick, et al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1. |
| Molecular Formula | C20H23N3O |
|---|---|
| Molecular Weight | 321.42 |