L-Methionine-DL-sulfoximine
L-Methionine-DL-sulfoximine structure
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Common Name | L-Methionine-DL-sulfoximine | ||
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| CAS Number | 15985-39-4 | Molecular Weight | 180.225 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 352.2±52.0 °C at 760 mmHg | |
| Molecular Formula | C5H12N2O3S | Melting Point | >210ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 166.8±30.7 °C | |
Use of L-Methionine-DL-sulfoximineL-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase. L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | L-methionine sulfoximine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | L-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase. L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 352.2±52.0 °C at 760 mmHg |
| Melting Point | >210ºC (dec.)(lit.) |
| Molecular Formula | C5H12N2O3S |
| Molecular Weight | 180.225 |
| Flash Point | 166.8±30.7 °C |
| Exact Mass | 180.056870 |
| PSA | 112.62000 |
| LogP | -1.38 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.560 |
| InChIKey | SXTAYKAGBXMACB-DPVSGNNYSA-N |
| SMILES | CS(=N)(=O)CCC(N)C(=O)O |
| Storage condition | 0-6°C |
| Stability | Temperature Sensitive |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925290090 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
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| DownStream 2 | |
![[R-(R*,S*)]-S-(3-amino-3-carboxypropyl)-S-methylsulphoximide structure](https://image.chemsrc.com/caspic/201/21752-31-8.png)
CAS#:21752-31-8![L-Methionine [S]-Sulfoximine structure](https://image.chemsrc.com/caspic/163/21752-32-9.png)
CAS#:21752-32-9This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2925290090 |
|---|---|
| Summary | 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Notch ligand delta-like1: X-ray crystal structure and binding affinity.
Biochem. J. 468 , 159-66, (2015) The Notch pathway is a fundamental signalling system in most multicellular animals. We have determined the X-ray crystal structure of the extracellular domain of the Notch ligand delta-like ligand-1 (... |
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Polyproline promotes tetramerization of recombinant human butyrylcholinesterase.
Biochem. J. 462(2) , 329-35, (2014) Human BChE (butyrylcholinesterase) protects against the toxicity of organophosphorus nerve agents and pesticides. BChE purified from human plasma is limited and pathogen carry-over is a concern. Unlik... |
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A Chimeric HIV-1 gp120 Fused with Vaccinia Virus 14K (A27) Protein as an HIV Immunogen.
PLoS ONE 10 , e0133595, (2015) In the HIV vaccine field, there is a need to produce highly immunogenic forms of the Env protein with the capacity to trigger broad B and T-cell responses. Here, we report the generation and character... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali...
Source: NCGC
External Id: adst_MBL_Abs_LOPAC_o1
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2
Source: NCGC
Target: eyes absent homolog 2 isoform a [Homo sapiens]
External Id: EYA2477
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2...
Source: NCGC
Target: ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens]
External Id: UBCH001
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Name: qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus...
Source: NCGC
Target: N/A
External Id: ZIK159
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
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Name: qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus...
Source: NCGC
Target: N/A
External Id: ZIK097
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Name: Vibrio cholerae assay for pro-quorum sensing small molecules
Source: Southern Research Specialized Biocontainment Screening Center
Target: cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961]
External Id: Vcholera_QS_Pilot
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| L-S-(3-Amino-3-carboxypropyl)-S-methylsulfoximine |
| 2-Amino-4-(S-methylsulfonimidoyl)butanoic acid |
| MFCD00002621 |
| UNII:M9P6YZ6JX9 |
| (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic acid |
| L-Methionine sulfoximine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of L-methionine sulfoximine? |
| A: Polar surface area (PSA) of L-methionine sulfoximine is 112.62000. |
| Q: What is the melting point of L-methionine sulfoximine? |
| A: Melting point of L-methionine sulfoximine is >210ºC (dec.)(lit.). |
| Q: What is the boiling point of L-methionine sulfoximine? |
| A: Boiling point of L-methionine sulfoximine is 352.2±52.0 °C at 760 mmHg. |
| Q: What is the InChIKey of L-methionine sulfoximine? |
| A: InChIKey of L-methionine sulfoximine is SXTAYKAGBXMACB-DPVSGNNYSA-N. |
| Q: What is the safety information for L-methionine sulfoximine? |
| A: Safety information for L-methionine sulfoximine: S26. |
| Q: What is the CAS number of L-methionine sulfoximine? |
| A: CAS number of L-methionine sulfoximine is 15985-39-4. |
| Q: What is the molecular weight of L-methionine sulfoximine? |
| A: Molecular weight of L-methionine sulfoximine is 180.225. |
| Q: What are the storage conditions for L-methionine sulfoximine? |
| A: Storage conditions for L-methionine sulfoximine: 0-6°C. |
| Q: What are the downstream products of L-methionine sulfoximine? |
| A: Related downstream products(CAS) of L-methionine sulfoximine: 21752-31-8;21752-32-9. |
| Q: What are the uses of L-methionine sulfoximine? |
| A: Main uses of L-methionine sulfoximine: L-Methionine-DL-sulfoximine (MSX) is an inhibitor of glutamine synthetase. L-Methionine-DL-sulfoximine is also a potent convulsant which metabolically and morphologically primarily affects astroglia. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |