NIBR 189

Modify Date: 2024-01-07 11:42:13

NIBR 189 Structure
NIBR 189 structure
Common Name NIBR 189
CAS Number 1599432-08-2 Molecular Weight 429.30700
Density N/A Boiling Point N/A
Molecular Formula C21H21BrN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NIBR 189


NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).IC50 value: 16/11 nM(Binding/Functional IC50) [1]Target: EBI2/GPR183 antagonistNIBR189 is a potent and selective EBI2 antagonist with improved pharmacokinetic properties which will help to probe the physiological function of EBI2 in health and disease.

 Names

Name nibr-189
Synonym More Synonyms

 NIBR 189 Biological Activity

Description NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).IC50 value: 16/11 nM(Binding/Functional IC50) [1]Target: EBI2/GPR183 antagonistNIBR189 is a potent and selective EBI2 antagonist with improved pharmacokinetic properties which will help to probe the physiological function of EBI2 in health and disease.
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References

[1]. Gessier F, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68.

 Chemical & Physical Properties

Molecular Formula C21H21BrN2O3
Molecular Weight 429.30700
Exact Mass 428.07400
PSA 49.85000
LogP 3.33130
Storage condition 2-8℃

 Synonyms

(E)-3-(4-bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one
NIBR189
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