TX2-121-1
Modify Date: 2025-08-24 20:07:22
TX2-121-1 structure
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Common Name | TX2-121-1 | ||
|---|---|---|---|---|
| CAS Number | 1603845-42-6 | Molecular Weight | 716.931 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C42H52N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TX2-121-1TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM. |
| Name | TX2-121-1 |
|---|
| Description | TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM. |
|---|---|
| References | References 1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12. View Related Products by Target EGFR |
| Molecular Formula | C42H52N8O3 |
|---|---|
| Molecular Weight | 716.931 |
| InChIKey | GKJWHLDKQULMHJ-ANSJYVPUSA-N |
| SMILES | C=CC(=O)Nc1cc(-c2nn(C3CCN(CCNC(=O)C(C)CCC45CC6CC(CC(C6)C4)C5)CC3)c3ncnc(N)c23)ccc1Oc1ccccc1 |