TX2-121-1 structure
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Common Name | TX2-121-1 | ||
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CAS Number | 1603845-42-6 | Molecular Weight | 716.931 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C42H52N8O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of TX2-121-1TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM. |
Name | TX2-121-1 |
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Description | TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor; induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization, induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM. |
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References | References 1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12. View Related Products by Target EGFR |
Molecular Formula | C42H52N8O3 |
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Molecular Weight | 716.931 |