CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE
Modify Date: 2024-01-15 15:04:08
CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE structure
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Common Name | CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINE | ||
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| CAS Number | 160754-76-7 | Molecular Weight | 351.92 | |
| Density | 1.25g/cm3 | Boiling Point | 529.2ºC at 760 mmHg | |
| Molecular Formula | C16H18ClN3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 273.8ºC | |
Use of CNS-5161,N'-(2-CHLORO-5-METHYLSULFANYL-PHENYL)-N-METHYL-N-(3-METHYLSULFANYL-PHENYL)-GUANIDINECNS-5161 is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. |
| Name | 2-(2-chloro-5-methylsulfanylphenyl)-1-methyl-1-(3-methylsulfanylphenyl)guanidine |
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| Synonym | More Synonyms |
| Description | CNS-5161 is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. |
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| Related Catalog | |
| Target |
NMDA receptor/ion channel[1] |
| In Vitro | CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain[1]. |
| In Vivo | In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1]. |
| References |
| Density | 1.25g/cm3 |
|---|---|
| Boiling Point | 529.2ºC at 760 mmHg |
| Molecular Formula | C16H18ClN3S2 |
| Molecular Weight | 351.92 |
| Flash Point | 273.8ºC |
| Exact Mass | 352.07100 |
| PSA | 91.66000 |
| LogP | 5.25770 |
| Vapour Pressure | 2.77E-11mmHg at 25°C |
| Index of Refraction | 1.627 |
| CNS-5161 |
| 2-[2-chloro-5-(methylsulfanyl)phenyl]-1-methyl-1-[3-(methylsulfanyl)phenyl]guanidine |