Dap-NE

Modify Date: 2024-01-18 19:12:04

Dap-NE Structure
Dap-NE structure
Common Name Dap-NE
CAS Number 160800-82-8 Molecular Weight 320.427
Density 1.1±0.1 g/cm3 Boiling Point 527.8±50.0 °C at 760 mmHg
Molecular Formula C18H28N2O3 Melting Point N/A
MSDS N/A Flash Point 273.0±30.1 °C

 Use of Dap-NE


Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162)[1].

 Names

Name (2R,3R)-N-[(1S,2R)-1-Hydroxy-1-phenyl-2-propanyl]-3-methoxy-2-methyl-3-[(2S)-2-pyrrolidinyl]propanamide
Synonym More Synonyms

 Dap-NE Biological Activity

Description Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162)[1].
Related Catalog
References

[1]. Xiao Chao, et al. Monomethyl auristatin E single crystal as standard or reference substance and preparation method thereof. China, CN116768966 A. 2023-09-19.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 527.8±50.0 °C at 760 mmHg
Molecular Formula C18H28N2O3
Molecular Weight 320.427
Flash Point 273.0±30.1 °C
Exact Mass 320.209991
LogP 1.06
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.531

 Synonyms

2-Pyrrolidinepropanamide, N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-β-methoxy-α-methyl-, (αR,βR,2S)-
(2R,3R)-N-[(1S,2R)-1-Hydroxy-1-phenyl-2-propanyl]-3-methoxy-2-methyl-3-[(2S)-2-pyrrolidinyl]propanamide