Mambalgin 1
Modify Date: 2025-08-27 15:29:01
Mambalgin 1 structure
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Common Name | Mambalgin 1 | ||
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| CAS Number | 1609937-15-6 | Molecular Weight | 7283.22 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C310H481N87O100S8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mambalgin 1Mambalgin 1 is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 binds to closed/inactive channel. Mambalgin 1 is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 increases latency of withdrawal response in mouse tail-flick and paw-flick tests. |
| Name | Mambalgin 1 |
|---|
| Description | Mambalgin 1 is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 binds to closed/inactive channel. Mambalgin 1 is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 increases latency of withdrawal response in mouse tail-flick and paw-flick tests. |
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| Related Catalog |
| Molecular Formula | C310H481N87O100S8 |
|---|---|
| Molecular Weight | 7283.22 |
| InChIKey | JRVGGBDTNREHFW-UHFFFAOYSA-N |
| SMILES | CCC(C)C1NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc2ccccc2)NC(=O)C2CCCN2C(=O)C(CCSC)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(CC(N)=O)NC(=O)C(Cc2c[nH]cn2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C2CSCC(NC(=O)C(CCCCN)NC(=O)C(N)CC(C)C)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(CCC(N)=O)C(=O)NC(Cc3c[nH]cn3)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CSSCC(C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC3CSSCC(C(=O)NC4CSSCC(C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CO)NC4=O)NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC3=O)NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC1=O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(Cc1ccccc1)C(=O)N2 |