PAO-Nap
Modify Date: 2025-09-18 21:00:32
PAO-Nap structure
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Common Name | PAO-Nap | ||
|---|---|---|---|---|
| CAS Number | 1613402-20-2 | Molecular Weight | 509.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H24AsN3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAO-NapPAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1]. |
| Name | PAO-Nap |
|---|
| Description | PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1]. |
| References |
| Molecular Formula | C24H24AsN3O5 |
|---|---|
| Molecular Weight | 509.39 |
| InChIKey | CVWSXPBPPSJPCI-UHFFFAOYSA-N |
| SMILES | Nc1ccc2c3c(cccc13)C(=O)N(CCCCCC(=O)Nc1ccc([As](O)O)cc1)C2=O |
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Name: Binding affinity to NADPH-reduced rat recombinant wild type TrxR after 30 mins by SDS...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3296173
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Name: Binding affinity to NADPH-reduced rat recombinant TrxR1 U498C mutant after 30 mins by...
Source: ChEMBL
Target: Thioredoxin reductase 1, cytoplasmic
External Id: CHEMBL3296174
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