flutimide

Modify Date: 2024-01-08 20:09:53

flutimide Structure
flutimide structure
Common Name flutimide
CAS Number 162666-34-4 Molecular Weight 238.28300
Density 1.18g/cm3 Boiling Point 354.8ºC at 760mmHg
Molecular Formula C12H18N2O3 Melting Point N/A
MSDS N/A Flash Point 168.4ºC

 Use of flutimide


Flutimide is a novel endonuclease inhibitor of influenza virus. Flutimide selectively inhibits endonuclease with an IC50 value of 3 μM. Flutimide shows antiviral activity in cell culture. Flutimide can be used for the research of acute contagious respiratory disease, such as influenza[1].

 Names

Name (5Z)-1-hydroxy-3-(2-methylpropyl)-5-(2-methylpropylidene)pyrazine-2,6-dione
Synonym More Synonyms

 flutimide Biological Activity

Description Flutimide is a novel endonuclease inhibitor of influenza virus. Flutimide selectively inhibits endonuclease with an IC50 value of 3 μM. Flutimide shows antiviral activity in cell culture. Flutimide can be used for the research of acute contagious respiratory disease, such as influenza[1].
Related Catalog
In Vitro Flutimide inhibits the cap-dependent endonuclease of influenza virus with an IC50 value of 3 μM[1].
References

[1]. Otto D. Hensens, et al. Isolation and structure of flutimide, a novel endonuclease inhibitor of influenza virus. (1995) 36(12), 2005–2008.

 Chemical & Physical Properties

Density 1.18g/cm3
Boiling Point 354.8ºC at 760mmHg
Molecular Formula C12H18N2O3
Molecular Weight 238.28300
Flash Point 168.4ºC
Exact Mass 238.13200
PSA 69.97000
LogP 1.14490
Vapour Pressure 1.86E-06mmHg at 25°C
Index of Refraction 1.55

 Synthetic Route

 Synonyms

Flutimide
(3Z)-1-Hydroxy-5-isobutyl-3-(2-methylpropylidene)pyrazine-2,6(1H,3H)-dione
2,6-(1H,3H)-Pyrazinedione,1-hydroxy-5-(2-methylpropyl)-3-(2-methylpropylidene)-,(3Z)
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