JG-231
Modify Date: 2024-01-02 09:10:10
JG-231 structure
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Common Name | JG-231 | ||
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| CAS Number | 1627126-59-3 | Molecular Weight | 619.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18BrCl2N3OS4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JG-231JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip). |
| Name | JG-231 |
|---|
| Description | JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip). |
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| References | References 1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C22H18BrCl2N3OS4 |
|---|---|
| Molecular Weight | 619.45 |