1627126-59-3
1627126-59-3 structure
- Name: JG-231
- Chemical Name: JG-231
- CAS Number: 1627126-59-3
- Molecular Formula: C22H18BrCl2N3OS4
- Molecular Weight: 619.45
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2020-01-11 19:46:50
- Modify Date: 2024-01-02 09:10:10
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JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip).
| Name | JG-231 |
|---|
| Description | JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip). |
|---|---|
| References | References 1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C22H18BrCl2N3OS4 |
|---|---|
| Molecular Weight | 619.45 |