(S)-3,5-DHPG

Modify Date: 2025-08-25 20:24:32

(S)-3,5-DHPG structure	Common Name	(S)-3,5-DHPG
	CAS Number	162870-29-3	Molecular Weight	183.161
	Density	1.5±0.1 g/cm3	Boiling Point	448.8±33.0 °C at 760 mmHg
	Molecular Formula	C₈H₉NO₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	225.2±25.4 °C

Use of (S)-3,5-DHPG

(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2].

Name	(S)-3,5-Dihydroxyphenylglycine hydrate
Synonym	More Synonyms

Description	(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR1a:0.9 μM (Ki) mGluR5a:3.9 μM (Ki)
In Vitro	(S)-3,5-DHPG specifically displaces high-affinity quisqualate sites, the putative group I mGlu binding sites[1].
In Vivo	(S)-3,5-DHPG (icv; 0.01, 0.1 and 1.0 nmol/5 μL) improves consolidation and retrieval and exhibits anxiolytic activity in dose-dependent manner in male Wistar rats weighing 160-180 g subjected to hypoxia[2].
References	[1]. V Mutel, et al. Characterization of [(3)H]Quisqualate Binding to Recombinant Rat Metabotropic Glutamate 1a and 5a Receptors and to Rat and Human Brain Sections. J Neurochem. 2000 Dec;75(6):2590-601. [2]. Agnieszka Nadlewska, et al. Effect of (S)-3,5-DHPG on Learning, Exploratory Activity and Anxiety in Rats With Experimental Hypoxia. Pol J Pharmacol. Jan-Feb 2002;54(1):11-8.

Density	1.5±0.1 g/cm3
Boiling Point	448.8±33.0 °C at 760 mmHg
Molecular Formula	C₈H₉NO₄
Molecular Weight	183.161
Flash Point	225.2±25.4 °C
Exact Mass	183.053162
PSA	103.78000
LogP	-0.52
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.680
InChIKey	HOOWCUZPEFNHDT-ZETCQYMHSA-N
SMILES	NC(C(=O)O)c1cc(O)cc(O)c1

(S)-3,5-DHPG MSDS(Chinese)

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Benzeneacetic acid, α-amino-3,5-dihydroxy-, (αS)-

(2S)-Amino(3,5-dihydroxyphenyl)acetic acid

Amino(3,5-dihydroxyphenyl)acetic acid

Benzeneacetic acid, α-amino-3,5-dihydroxy-

(2S)-amino(3,5-dihydroxyphenyl)ethanoic acid

UNII:5YR2N37E6D

(S)-3,5-DHPG,(S)-3,5-Dihydroxyphenylglycine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S)-3,5-DHPG
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Dihydroxyphenylglycine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg ￥220.0/10ml
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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(S)-3,5-DHPG

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.