PD 0332991-d8

Modify Date: 2024-01-13 10:00:50

PD 0332991-d8 structure	Common Name	PD 0332991-d8
	CAS Number	1628752-83-9	Molecular Weight	455.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₁D₈N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PD 0332991-d8

Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities[1].

Name	Palbociclib D8

Description	Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Cdk4/cyclin D3:9 nM (IC50) Cdk4/cyclin D1:11 nM (IC50) Cdk6/cyclin D2:16 nM (IC50) DYRK1A:2000 nM (IC50) MAPK:8000 nM (IC50)
References	[1]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

Molecular Formula	C₂₄H₂₁D₈N₇O₂
Molecular Weight	455.58
Storage condition	-20°C

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China
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