Irsenontrine maleate

Modify Date: 2024-01-10 18:54:18

Irsenontrine maleate Structure
Irsenontrine maleate structure
Common Name Irsenontrine maleate
CAS Number 1630083-70-3 Molecular Weight 506.51
Density N/A Boiling Point N/A
Molecular Formula C26H26N4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Irsenontrine maleate


Irsenontrine (E2027) maleate is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases[1][2].

 Names

Name Irsenontrine maleate

 Irsenontrine maleate Biological Activity

Description Irsenontrine (E2027) maleate is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases[1][2].
Related Catalog
Target

PDE9[1]

In Vivo Irsenontrine (0.3, 3.3 mg/kg; p.o.) maleate exhibits a significant ameliorative effect on the percentage of exploration of the novel object at 3.3 mg/kg in Scopolamine-induced rats[1]. Irsenontrine (1 mg/kg; p.o.) maleate and memantine hydrochloride (1 mg/kg; p.o.) combined treatment group exhibits a significantly higher percentage of exploration of the novel object than memantine hydrochloride (1 mg/kg) alone[1].
References

[1]. Miyamoto, et al. Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine. WO2018221550 A1

[2]. Hershey LA, et al. Pharmacological Management of Dementia with Lewy Bodies. Drugs Aging. 2019;36(4):309-319.

[3]. Eisai to present latest research on Alzheimer’s disease / dementia pipeline at the 14th international conference on Alzheimer’s & Parkinson’s diseases

 Chemical & Physical Properties

Molecular Formula C26H26N4O7
Molecular Weight 506.51
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