BAR501
Modify Date: 2024-01-02 22:08:29
BAR501 structure
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Common Name | BAR501 | ||
|---|---|---|---|---|
| CAS Number | 1632118-69-4 | Molecular Weight | 406.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H46O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAR501BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. |
| Name | BAR 501 |
|---|---|
| Synonym | More Synonyms |
| Description | BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 1 μM (GPBAR1)[1] |
| In Vitro | BAR501 is a selective GPBAR1 agonist devoid of FXR agonistic activity. It effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with an EC50 of 1 μM. Exposure of GLUTAg cells to BAR501 (10 μM) increases the expression of GLP-1 mRNA by 2.5 folds[1]. |
| In Vivo | Pretreating rats for 6 days with BAR501, 15 mg/kg, reduces basal portal pressure and blunts the vasoconstriction activity of norepinephrine. Pretreatment with BAR501 attenuates the hepatic vasomotor activity induced by shear stress and methoxamine. Administration of BAR501 exerts a direct vasodilatory activity in the CCl4 model. Treating mice with BAR501 at the dose of 15 mg/Kg reduces portal pressure and AST plasma levels. BAR501 attenuates endothelial dysfunction by regulating CSE expression/activity[1]. |
| Cell Assay | For GPBAR1 mediated transactivation, HEK-293T cells are plated at 10000 cells/well in a 24 well-plate and transfected with 200 ng of pGL4.29, a reporter vector containing a cAMP response element (CRE) that drives the transcription of the luciferase reporter gene luc2P, with 100 ng of pCMVSPORT6-human GPBAR1, and with 100 ng of pGL4.70. At 24 h post-transfection, HepG2 and HEK293T cells are incubated with 10 μM BAR501 for 18 h and luciferase activities are assayed and normalized against the Renilla activities[1]. |
| Animal Admin | Mice: C57BL6 mice are administered i.p. 500 μL/Kg body weight of CCl4 in an equal volume of paraffin oil twice a week for 9 weeks. CCL4 mice are randomized to receive BAR501 (15 mg/Kg daily by gavage) or vehicle (distilled water). Serum bilirubin, albumin, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase are measured by routine biochemical clinical chemistry[1]. |
| References |
| Molecular Formula | C26H46O3 |
|---|---|
| Molecular Weight | 406.64 |
| Storage condition | -20℃ |
| BAR501 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: BAR501
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: BAR501
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: BAR501
- Price: $900.0/100mg $1800.0/250mg $3600.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: $140/10mM*1mLinDMSO
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