Kadsulignan N

Modify Date: 2024-01-11 17:38:37

Use of Kadsulignan N

Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].

Name	(1R,14S,15S,16R)-4,5,6,9,10,11-Hexamethoxy-15,16-dimethyl-17-oxatetracyclo[12.2.1.02,7.08,13]heptadeca-2,4,6,8,10,12-hexaene
Synonym	More Synonyms

Description	Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2
In Vitro	Kadsulignans N 对 COX-2 表现出较弱的抑制活性，IC50值为 600.54 μM[2]。
References	[1]. Gao XM, et al. Lignans from Kadsura angustifolia. J Nat Prod. 2008 Apr;71(4):558-63. [2]. Zhang XY, et al. Discovery of cyclooxygenase-2 inhibitors from Kadsura coccinea by affinity ultrafiltration mass spectrometry and the anti-inflammatory activity. Fitoterapia. 2021 Jun;151:104872.

(1R,14S,15S,16R)-4,5,6,9,10,11-Hexamethoxy-15,16-dimethyl-17-oxatetracyclo[12.2.1.0.0]heptadeca-2,4,6,8,10,12-hexaene

5,8-Epoxydibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (5R,6R,7S,8S)-

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