AZITHROMYCIN-D3

Modify Date: 2024-01-09 11:43:39

AZITHROMYCIN-D3 Structure
AZITHROMYCIN-D3 structure
Common Name AZITHROMYCIN-D3
CAS Number 163921-65-1 Molecular Weight 748.98448
Density N/A Boiling Point N/A
Molecular Formula C38H72N2O12 Melting Point 125-1290C
MSDS N/A Flash Point N/A

 Use of AZITHROMYCIN-D3


Azithromycin-d3 (CP 62993-d3) is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].

 Names

Name AZITHROMYCIN-D3

 AZITHROMYCIN-D3 Biological Activity

Description Azithromycin-d3 (CP 62993-d3) is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.

[3]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

 Chemical & Physical Properties

Melting Point 125-1290C
Molecular Formula C38H72N2O12
Molecular Weight 748.98448
Storage condition -20°C Freezer, Under Inert Atmosphere