cis-Epoxysuccinic Acid
Modify Date: 2024-01-02 19:27:14
cis-Epoxysuccinic Acid structure
|
Common Name | cis-Epoxysuccinic Acid | ||
|---|---|---|---|---|
| CAS Number | 16533-72-5 | Molecular Weight | 132.072 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 467.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C4H4O5 | Melting Point | 148-149 °C | |
| MSDS | N/A | Flash Point | 215.7±22.2 °C | |
Use of cis-Epoxysuccinic Acidcis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1]. |
| Name | cis-Epoxysuccinic Acid |
|---|---|
| Synonym | More Synonyms |
| Description | cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1]. |
|---|---|
| Related Catalog | |
| In Vitro | cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1]. cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1]. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 1, 10 and 100 μM Incubation Time: 10 min Result: Inhibited cAMP levels with an EC50 value of 2.7 µM. Cell Viability Assay[1] Cell Line: HEK293 cells Concentration: 0.1 μM-100 mM Incubation Time: 1 hour Result: Induced the Gq pathway, recruited arrestin 3 and elicited [Ca2+]i mobilization with EC50 values of 42, 74 and 191 µM, respectively. |
| In Vivo | cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1]. Animal Model: Male Wistar rats[1] Dosage: 1 mg/kg Administration: Intravenous injection; 1 mg/kg once Result: Showed in vivo activity and increased blood pressure after injection. |
| References |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 467.5±45.0 °C at 760 mmHg |
| Melting Point | 148-149 °C |
| Molecular Formula | C4H4O5 |
| Molecular Weight | 132.072 |
| Flash Point | 215.7±22.2 °C |
| Exact Mass | 132.005875 |
| PSA | 87.13000 |
| LogP | -1.25 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.585 |
| Hazard Codes | C: Corrosive; |
|---|---|
| Risk Phrases | 34-2 |
| Safety Phrases | S45-S36/37/39-S26 |
| HS Code | 2918990090 |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| MFCD00191645 |
| EINECS 240-604-3 |
| CIS-EPOXYSUCCINIC ACID |
| cis-2,3-Oxiranedicarboxylic Acid |