Fmoc-NH-PEG1-C2-acid

Modify Date: 2024-01-11 15:15:16

Fmoc-NH-PEG1-C2-acid Structure
Fmoc-NH-PEG1-C2-acid structure
Common Name Fmoc-NH-PEG1-C2-acid
CAS Number 1654740-73-4 Molecular Weight 355.384
Density 1.3±0.1 g/cm3 Boiling Point 589.9±40.0 °C at 760 mmHg
Molecular Formula C20H21NO5 Melting Point N/A
MSDS N/A Flash Point 310.6±27.3 °C

 Use of Fmoc-NH-PEG1-C2-acid


Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethoxy)propanoic acid
Synonym More Synonyms

 Fmoc-NH-PEG1-C2-acid Biological Activity

Description Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 589.9±40.0 °C at 760 mmHg
Molecular Formula C20H21NO5
Molecular Weight 355.384
Flash Point 310.6±27.3 °C
Exact Mass 355.141968
LogP 3.37
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.589

 Synonyms

MFCD16294357
Propanoic acid, 3-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]-
3-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethoxy)propanoic acid
Fmoc-6-Amino-4-oxahexanoic acid
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