L-Leucyl-L-Leucine methyl ester hydrobromide

Modify Date: 2024-01-06 11:20:29

L-Leucyl-L-Leucine methyl ester hydrobromide Structure
L-Leucyl-L-Leucine methyl ester hydrobromide structure
Common Name L-Leucyl-L-Leucine methyl ester hydrobromide
CAS Number 16689-14-8 Molecular Weight 339.26900
Density N/A Boiling Point N/A
Molecular Formula C13H27BrN2O3 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of L-Leucyl-L-Leucine methyl ester hydrobromide


L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress[1][2][3].

 Names

Name Leu-Leu methyl ester hydrobromide
Synonym More Synonyms

  Biological Activity

Description L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress[1][2][3].
Related Catalog
In Vitro L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[3]. L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[2].
References

[1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48.

[2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7.

[3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423.

 Chemical & Physical Properties

Molecular Formula C13H27BrN2O3
Molecular Weight 339.26900
Exact Mass 338.12100
PSA 81.42000
LogP 3.11300

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924199090

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

methyl 2-[(2-amino-4-methylpentanoyl)amino]-4-methylpentanoate,hydrobromide
LLME,HBr Leu-Leu-Ome,HBr
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