BMS 453
Modify Date: 2024-01-09 15:07:19
BMS 453 structure
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Common Name | BMS 453 | ||
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| CAS Number | 166977-43-1 | Molecular Weight | 380.47800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H24O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of BMS 453BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[1][2]. |
| Name | 4-[(E)-2-(5,5-Dimethyl-8-phenyl-5,6-dihydro-2-naphthalenyl)vinyl] benzoic acid |
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| Synonym | More Synonyms |
| Description | BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[1][2]. |
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| Related Catalog | |
| In Vitro | BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2]. BMS453 (1 μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest[2]. BMS453 (1 μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21[2]. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[2]. Cell Proliferation Assay[2] Cell Line: Normal human mammary epithelial cells (184 and HMEC) Concentration: 1 μM Incubation Time: 11 hours Result: Inhibited 3H-thymidine uptake in normal breast cells (184 and HMEC) by 40 %. Cell Cycle Analysis[2] Cell Line: Normal human mammary epithelial cells (184 and HMEC) Concentration: 1 μM Incubation Time: 5 days Result: Increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase. Western Blot Analysis[2] Cell Line: 184 cells Concentration: 1 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Induced Rb hypophosphorylation and decrease CDK2 kinase activity. |
| References |
| Molecular Formula | C27H24O2 |
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| Molecular Weight | 380.47800 |
| Exact Mass | 380.17800 |
| PSA | 37.30000 |
| LogP | 6.66820 |
| RIDADR | NONH for all modes of transport |
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| BMS-189453 |