PT-2385
Modify Date: 2024-01-10 04:53:52
PT-2385 structure
|
Common Name | PT-2385 | ||
|---|---|---|---|---|
| CAS Number | 1672665-49-4 | Molecular Weight | 383.342 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 524.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H12F3NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 271.1±30.1 °C | |
Use of PT-2385PT-2385 is a selective HIF-2α antagonist with a Ki of less than 50 nM. |
| Name | PT2385 |
|---|---|
| Synonym | More Synonyms |
| Description | PT-2385 is a selective HIF-2α antagonist with a Ki of less than 50 nM. |
|---|---|
| Related Catalog | |
| Target |
Kd: <50 nM (HIF-2α)[1] |
| In Vitro | PT-2385 (PT2385) is a selective antagonist of HIF-2 over HIF-1. PT-2385 is inactive for HIF-1α[1]. |
| In Vivo | PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31)[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.7±50.0 °C at 760 mmHg |
| Molecular Formula | C17H12F3NO4S |
| Molecular Weight | 383.342 |
| Flash Point | 271.1±30.1 °C |
| Exact Mass | 383.043915 |
| LogP | 1.80 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.613 |
| Storage condition | 2-8℃ |
| Benzonitrile, 3-[[(1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro- |
| 3-{[(1S)-2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile |
| PT-2385 |