Astressin TFA
Astressin TFA structure
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Common Name | Astressin TFA | ||
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| CAS Number | 170809-51-5 | Molecular Weight | 3563.16000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C161H269N49O42 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Astressin TFAAstressin is a potent corticotropin releasing factor (CRF) antagonist. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | astressin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Astressin is a potent corticotropin releasing factor (CRF) antagonist. |
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| Related Catalog | |
| In Vitro | Astressin has low affinity for the CRF binding protein and high affinity (Ki=2 nM) for the cloned pituitary receptor. Astressin shows high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion[1]. |
| In Vivo | Astressin is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin (ACTH) secretion in stressed or adrenalectomized rats. Low doses of astressin (30 μg and 100 μg per kg) administered i.v. still produce a significant decrease in ACTH levels at 45 and 90 min, respectively[1]. Astressin significantly reverses the anxiogenic-like response induced by both social stress and ICV rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment[2]. Intracerebroventricular infusion of the peptide both 30 min before and 10 min after seizures decreases damage in some hippocampal cell fields by as much as 84%, a magnitude of protection greater than reported for other CRF antagonists against other models of necrotic neuronal injury. Astressin protects even if administered only 10 min following excitotoxin exposure[3]. |
| Animal Admin | Rats: Rat diet is supplemented with oranges, and their water contained 0.9% NaCl. They are equipped with indwelling jugular cannulae 48 h prior to the i.v. injection of either vehicle or astressin. Astressin is first diluted in sterile, distilled, apyrogenic water, and the pH is adjusted to 7.0. Further dilutions are made in 0.04 M phosphate buffer, pH 7.4, containing 0.1% bovine serum albumin and 0.01% ascorbic acid. Blood samples are obtained immediately before treatment, as well as 15-120 min later. Decanted plasma samples are frozen until assayed for ACTH concentrations[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C161H269N49O42 |
|---|---|
| Molecular Weight | 3563.16000 |
| Exact Mass | 3561.04000 |
| PSA | 1489.66000 |
| LogP | 9.58910 |
| InChIKey | HPYIIXJJVYSMCV-UHFFFAOYSA-N |
| SMILES | CCCCC(NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(N)Cc1ccccc1)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(C(N)=O)C(C)CC)C(C)CC)NC(=O)C(Cc2c[nH]cn2)NC(=O)C(C)NC1=O |
| Storage condition | 2-8℃ |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Neurokinin B signaling in the female rat: a novel link between stress and reproduction.
Endocrinology 155(7) , 2589-601, (2014) Acute systemic stress disrupts reproductive function by inhibiting pulsatile gonadotropin secretion. The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the funct... |
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Corticotropin-releasing hormone and the sympathoadrenal system are major mediators in the effects of peripherally administered exendin-4 on the hypothalamic-pituitary-adrenal axis of male rats.
Endocrinology 155(7) , 2511-23, (2014) Glucagon-like peptide-1 (GLP-1) and the GLP-1 receptor agonist, exendin-4 (Ex-4), potently stimulate hypothalamic-pituitary-adrenal (HPA) axis activity after either central or peripheral administratio... |
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Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration.
J. Neurosci. 34(19) , 6659-67, (2014) The nature of neuroadaptations in the genesis of escalated cocaine taking remains a topic of considerable interest. Intermittent social defeat stress induces both locomotor and dopaminergic cross-sens... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Rat CRF2 receptor (Corticotropin-releasing factor receptors)
Source: IUPHAR-DB
Target: CRF2 receptor (Corticotropin-releasing factor receptors) [Rattus norvegicus]
External Id: 213_Rat
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Name: Human CRF2 receptor (Corticotropin-releasing factor receptors)
Source: IUPHAR-DB
Target: CRF2 receptor (Corticotropin-releasing factor receptors) [Homo sapiens]
External Id: 213_Human
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Name: Mouse CRF2 receptor (Corticotropin-releasing factor receptors)
Source: IUPHAR-DB
Target: CRF2 receptor (Corticotropin-releasing factor receptors) [Mus musculus]
External Id: 213_Mouse
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Astressin |
| M.W. 3563.24 C161H269N49O42 |
| [D-Phe12,Nle21,38,Glu30 |
| ASTRESSIN TRIFLUOROACETATE SALT |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of astressin? |
| A: InChIKey of astressin is HPYIIXJJVYSMCV-UHFFFAOYSA-N. |
| Q: What are the storage conditions for astressin? |
| A: Storage conditions for astressin: 2-8℃. |
| Q: What English synonyms does astressin have? |
| A: English synonyms of astressin: Astressin, M.W. 3563.24 C161H269N49O42, [D-Phe12,Nle21,38,Glu30, ASTRESSIN TRIFLUOROACETATE SALT. |
| Q: What is the molecular weight of astressin? |
| A: Molecular weight of astressin is 3563.16000. |
| Q: What is the CAS number of astressin? |
| A: CAS number of astressin is 170809-51-5. |
| Q: What is the LogP of astressin? |
| A: LogP of astressin is 9.58910. |
| Q: What is the Chinese name of 170809-51-5? |
| A: Chinese name of 170809-51-5 is DPHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-NLE-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLU-ALA-HIS-LYS-ASN-ARG-LYS-LEU-NLE-GLU-ILE-ILE-NH2. |
| Q: What is the SMILES notation of astressin? |
| A: SMILES notation of astressin is CCCCC(NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(N)Cc1ccccc1)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(C(N)=O)C(C)CC)C(C)CC)NC(=O)C(Cc2c[nH]cn2)NC(=O)C(C)NC1=O. |
| Q: What is the molecular formula of astressin? |
| A: Molecular formula of astressin is C161H269N49O42. |
| Q: What is the polar surface area (PSA) of astressin? |
| A: Polar surface area (PSA) of astressin is 1489.66000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |