PB 28 dihydrochloride
Modify Date: 2024-01-16 18:04:27
PB 28 dihydrochloride structure
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Common Name | PB 28 dihydrochloride | ||
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| CAS Number | 172907-03-8 | Molecular Weight | 443.493 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H40Cl2N2O | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | N/A | |
Use of PB 28 dihydrochlorideA potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively; inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range; increase G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression. |
| Name | PB28 dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively; inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range; increase G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression. |
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| References | References 1. Azzariti A, et al. Mol Cancer Ther. 2006 Jul;5(7):1807-16. 2. Cassano G, et al. Cell Calcium. 2006 Jul;40(1):23-8. 3. Berardi F, et al. J Med Chem. 1996 Jan 5;39(1):176-82. View Related Products by Target Sigma Receptor |
| Molecular Formula | C24H40Cl2N2O |
|---|---|
| Molecular Weight | 443.493 |
| Exact Mass | 442.251770 |
| 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-1-naphthalenyl)propyl]piperazine dihydrochloride |
| PB28 dihydrochloride |
| 1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride |
| MFCD06798349 |
| Piperazine, 1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-, hydrochloride (1:2) |