Tyrosylleucine

Modify Date: 2025-08-20 18:10:04

Use of Tyrosylleucine

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

Name	Tyr-Leu
Synonym	More Synonyms

Description	Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1]. Animal Model: Male ddY mice (24-27 g)[1] Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o. Administration: Administered orally, intracerebroventricularly, or intraperitoneally Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST. Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.
References	[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257. [2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

WGK Germany	3
HS Code	2924299090

Precursor 1
CAS#:35971-70-1 Z-Tyr-Leu-OH
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-L-Tyrosyl-L-leucin

TYR-LEU

L-Leucine,N-L-tyrosyl

N-L-tyrosyl-L-leucine

tyrosylleucine

L-Tyrosyl-L-leucine

L-Tyrosyl-L-leucin

H-TYR-LEU-OH

L-tyrosine-L-leucine

TYR-LEU CRYSTALLINE

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-2-((S)-2-AMINO-3-(4-HYDROXYPHENYL)PROPANAMIDO)-4-METHYLPENTANOIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥351/250mg

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