Tyrosylleucine TFA

Modify Date: 2024-01-03 13:23:55

Tyrosylleucine TFA Structure
Tyrosylleucine TFA structure
Common Name Tyrosylleucine TFA
CAS Number 66852-01-5 Molecular Weight 408.37
Density N/A Boiling Point N/A
Molecular Formula C17H23F3N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tyrosylleucine TFA


Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

 Names

Name L-Tyr-L-Leu-OH trifluoroacetate

 Tyrosylleucine TFA Biological Activity

Description Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Related Catalog
In Vitro Tyrosylleucine (Tyr-Leu, YL) increases the amount of cells expressing c-Fos, a marker for neuronal activity, in the dentate gyrus of the hippocampus[1].
In Vivo Tyrosylleucine (Tyr-Leu, YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.)[2].
References

[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

[2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

 Chemical & Physical Properties

Molecular Formula C17H23F3N2O6
Molecular Weight 408.37
Exact Mass 408.15100
PSA 149.95000
LogP 2.60200

 Precursor & DownStream

Precursor  0

DownStream  2

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