Tyrosylleucine TFA

Modify Date: 2026-06-30 19:23:09

Tyrosylleucine TFA Structure
Tyrosylleucine TFA structure
Common Name Tyrosylleucine TFA
CAS Number 66852-01-5 Molecular Weight 408.37
Density N/A Boiling Point N/A
Molecular Formula C17H23F3N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tyrosylleucine TFA


Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name L-Tyr-L-Leu-OH trifluoroacetate

 Tyrosylleucine TFA Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Related Catalog
In Vitro Tyrosylleucine (Tyr-Leu, YL) increases the amount of cells expressing c-Fos, a marker for neuronal activity, in the dentate gyrus of the hippocampus[1].
In Vivo Tyrosylleucine (Tyr-Leu, YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.)[2].
References

[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

[2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula C17H23F3N2O6
Molecular Weight 408.37
Exact Mass 408.15100
PSA 149.95000
LogP 2.60200
InChIKey ITCLJBVMTNXDJY-QNTKWALQSA-N
SMILES CC(C)CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O.O=C(O)C(F)(F)F

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  0

DownStream  2

 Tyrosylleucine TFA | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of L-Tyr-L-Leu-OH trifluoroacetate?
A: The English name of L-Tyr-L-Leu-OH trifluoroacetate is L-Tyr-L-Leu-OH trifluoroacetate.
Q: What is the polar surface area (PSA) of L-Tyr-L-Leu-OH trifluoroacetate?
A: Polar surface area (PSA) of L-Tyr-L-Leu-OH trifluoroacetate is 149.95000.
Q: What is the molecular weight of L-Tyr-L-Leu-OH trifluoroacetate?
A: Molecular weight of L-Tyr-L-Leu-OH trifluoroacetate is 408.37.
Q: What is the SMILES notation of L-Tyr-L-Leu-OH trifluoroacetate?
A: SMILES notation of L-Tyr-L-Leu-OH trifluoroacetate is CC(C)CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O.O=C(O)C(F)(F)F.
Q: What is the CAS number of L-Tyr-L-Leu-OH trifluoroacetate?
A: CAS number of L-Tyr-L-Leu-OH trifluoroacetate is 66852-01-5.
Q: What is the LogP of L-Tyr-L-Leu-OH trifluoroacetate?
A: LogP of L-Tyr-L-Leu-OH trifluoroacetate is 2.60200.
Q: What is the molecular formula of L-Tyr-L-Leu-OH trifluoroacetate?
A: Molecular formula of L-Tyr-L-Leu-OH trifluoroacetate is C17H23F3N2O6.
Q: What is the Chinese name of 66852-01-5?
A: Chinese name of 66852-01-5 is Tyrosylleucine TFA.
Q: What is the InChIKey of L-Tyr-L-Leu-OH trifluoroacetate?
A: InChIKey of L-Tyr-L-Leu-OH trifluoroacetate is ITCLJBVMTNXDJY-QNTKWALQSA-N.
Q: What are the downstream products of L-Tyr-L-Leu-OH trifluoroacetate?
A: Related downstream products(CAS) of L-Tyr-L-Leu-OH trifluoroacetate: 61-90-5;60-18-4.

 Tyrosylleucine TFAfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
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