Gambogenic acid
Modify Date: 2024-01-03 18:45:04
Gambogenic acid structure
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Common Name | Gambogenic acid | ||
|---|---|---|---|---|
| CAS Number | 173932-75-7 | Molecular Weight | 630.767 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 818.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C38H46O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 253.0±27.8 °C | |
Use of Gambogenic acidGambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1]. |
| Name | Gambogenic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1]. |
|---|---|
| Related Catalog | |
| Target |
EZH2[1] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 818.6±65.0 °C at 760 mmHg |
| Molecular Formula | C38H46O8 |
| Molecular Weight | 630.767 |
| Flash Point | 253.0±27.8 °C |
| Exact Mass | 630.319275 |
| LogP | 9.42 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.619 |
| Storage condition | 2-8°C |
| (2Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methyl-2-buten-1-yl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.0.0.0]octadeca-4,6,8,11- tetraen-15-yl]-2-methyl-2-butenoic acid |
| 2-Butenoic acid, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-, (2Z)- |
| (2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid |