| Description |
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygenspecies (ROS) accumulation and supressesthe activation of ERK 1/2. Pinealon has the ability to stimulate the functional activity of the main cellular elements of brain tissue, reduce the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].
|
| Related Catalog |
|
| In Vitro |
Pinealon (10, 50, 100 nM; 30 min) 以剂量依赖性方式阻止哇巴因诱导的小脑颗粒细胞中 ROS 积累的增加[1]。 Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) 抑制暴露于 500 mM 同型半胱氨酸 (HC) 的大鼠小脑颗粒细胞中 ERK 1/2 的激活[1]。
|
| In Vivo |
Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) 对维持大鼠先前获得的技能显示出剂量依赖性作用[2]。 Pinealon (10 µg/kg; daily for 5 days) 保护大鼠后代免受产前高同型半胱氨酸血症[3]。 Animal Model: 200-250 g, white male rats[2] Dosage: 50, 100, 200 ng/kg Administration: Injection; for 5 days Result: Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze. Animal Model: 180-200 g, Female Wistar rats[3] Dosage: 10 µg/kg Administration: I.p.; daily for 5 days Result: Protected the rat offspring from prenatal hyperhomocysteinemia.
|
| References |
[1]. Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14(5):535-41. [2]. G. V. Karantysh, et al. Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes. Neurochemical Journal, 2020, 14, 314-320. [3]. Arutjunyan A, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85.
|
