S 18986
Modify Date: 2024-01-19 15:17:55
S 18986 structure
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Common Name | S 18986 | ||
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| CAS Number | 175340-20-2 | Molecular Weight | 224.27900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H12N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S 18986S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2]. |
| Name | (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide |
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| Description | S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2]. |
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| Related Catalog | |
| In Vivo | S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models [1]. S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation[1]. Animal Model: Middle-aged (14-15-months-old) mice[1] Dosage: 0.3, 1, and 10 mg/kg Administration: p.o. Result: Showed antiamnesic properties in middle-aged rodents. |
| References |
| Molecular Formula | C10H12N2O2S |
|---|---|
| Molecular Weight | 224.27900 |
| Exact Mass | 224.06200 |
| PSA | 57.79000 |
| LogP | 2.37940 |
| Storage condition | -20°C |