6-(Methylsulfonyl)-1,3-benzothiazol-2-amine

Modify Date: 2024-01-02 19:53:08

6-(Methylsulfonyl)-1,3-benzothiazol-2-amine structure	Common Name	6-(Methylsulfonyl)-1,3-benzothiazol-2-amine
	CAS Number	17557-67-4	Molecular Weight	228.29
	Density	1.5±0.1 g/cm3	Boiling Point	500.8±56.0 °C at 760 mmHg
	Molecular Formula	C₈H₈N₂O₂S₂	Melting Point	223 °C (dec.)(lit.)
	MSDS	N/A	Flash Point	256.7±31.8 °C

Use of 6-(Methylsulfonyl)-1,3-benzothiazol-2-amine

TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC50s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC50: 34.2 μM)[1].

Name	2-Amino-6-(Methylsulfonyl)Benzothiazole
Synonym	More Synonyms

Description	TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC50s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC50: 34.2 μM)[1].
Related Catalog	Research Areas >> Infection
References	[1]. Linciano P, et al. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J Med Chem. 2019 Apr 25;62(8):3989-4012.

Density	1.5±0.1 g/cm3
Boiling Point	500.8±56.0 °C at 760 mmHg
Melting Point	223 °C (dec.)(lit.)
Molecular Formula	C₈H₈N₂O₂S₂
Molecular Weight	228.29
Flash Point	256.7±31.8 °C
Exact Mass	228.002716
PSA	109.67000
LogP	0.17
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.688

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL0863408

CHEMICAL NAME :: 2-Benzothiazolamine, 6-(methylsulfonyl)-

CAS REGISTRY NUMBER :: 17557-67-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534339

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534339

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S36/37/39-S22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	DL0863408
HS Code	2934999090

Precursor 8
CAS#:5470-49-5 4-(Methylsulfon... CAS#:84783-67-5 1-(4-methylsulp... CAS#:50850-92-5 6-(methylthio)b... CAS#:701-57-5 4-nitrophenyl m...
CAS#:854067-76-8 N-(6-methylsulf... CAS#:2976-30-9 Methyl 4-nitrop... CAS#:65069-54-7 1-(4-(methylthi... CAS#:540-72-7 Sodium thiocyanate
DownStream 1
CAS#:3622-29-5 2-CHLORO-6-(MET...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-amino-6-(methylsulfonyl)benzothiazole

6-(Methylsulfonyl)-1,3-benzothiazol-2-amine

MFCD00179133

2-Amino-6-methylsulfonylbenzothiazole

6-methylsulfonyl-1,3-benzothiazol-2-amine

2-Benzothiazolamine, 6-(methylsulfonyl)-

EINECS 241-537-2

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 6-(Methylsulfonyl)-1,3-benzothiazol-2-amine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6-(Methylsulfonyl)-1,3-benzothiazol-2-amine
Price: ￥988.0/5g ￥328.0/1g
Purity: 97.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Amino-6-methylsulfonylbenzothiazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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