Nicotiflorin
Modify Date: 2026-07-01 16:15:40
Nicotiflorin structure
|
Common Name | Nicotiflorin | ||
|---|---|---|---|---|
| CAS Number | 17650-84-9 | Molecular Weight | 594.518 | |
| Density | 1.76 | Boiling Point | 941.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C27H30O15 | Melting Point | 181-186 ºC | |
| MSDS | Chinese USA | Flash Point | 312.8±27.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NicotiflorinNicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Flos Carthami. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | kaempferol-3-rutinoside |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Flos Carthami. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. |
|---|---|
| Related Catalog | |
| Target |
Antiglycation[1] |
| In Vitro | For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron[2]. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions[3]. |
| In Vivo | At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits[2]. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits[3]. |
| Cell Assay | Cortical neurons are treated with nicotiflorin (25-100 mg/mL) just before hypoxia. Cell viability is determined using the MTT assay[2]. |
| Animal Admin | Rats[2] A neurological examination is performed on each rat 24 h after the onset of ischemia. Briefly, neurological scores (NS) are derived using a 10-point sliding scale. Rats are administered 2.5, 5, and 10 mg/kg nicotiflorin or vehicle immediately after occlusion. Each animal is examined for reduced resistance to lateral push (score, 4), open field circling (score, 3), and shoulder adduction (score, 2) or contralateral forelimb flexion (score, 1) when held by the tail and suspended approximately 0.5 m above the floor. Rats extending both forelimbs toward the floor and not showing any other signs of neurological impairment are scored 0[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.76 |
|---|---|
| Boiling Point | 941.7±65.0 °C at 760 mmHg |
| Melting Point | 181-186 ºC |
| Molecular Formula | C27H30O15 |
| Molecular Weight | 594.518 |
| Flash Point | 312.8±27.8 °C |
| Exact Mass | 594.158447 |
| PSA | 249.20000 |
| LogP | 1.96 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.744 |
| Storage condition | ?20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Fluorescent Cell-Based Secondary Screen to Identify Activators of the Hypoxia Factor ...
Source: Broad Institute
Target: N/A
External Id: 2030-03_ACTIVATORS_DOSE-TITRATION_MLPCN-CHERRYPICK
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: Antineuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-...
Source: ChEMBL
Target: BV-2
External Id: CHEMBL2215174
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Inhibition of Clostridium perfringens neuraminidase
Source: ChEMBL
Target: Sialidase
External Id: CHEMBL1065350
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| kaempferol-3-O-rutinoside |
| Nicotiflorin |
| Kaempferol 3-O-rutinose |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside |
| Nicotiflorine |
| kaempferol 3-O-rutinoside |
| NICOTIFLOROSIDE |
| Kaempferol 3-O-β-rutinoside |
| Kaempferol-3-rutinoside |
| kaempferol-3-rhamnoglucoside |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of kaempferol-3-rutinoside? |
| A: Melting point of kaempferol-3-rutinoside is 181-186 ºC. |
| Q: What is the boiling point of kaempferol-3-rutinoside? |
| A: Boiling point of kaempferol-3-rutinoside is 941.7±65.0 °C at 760 mmHg. |
| Q: What is the safety information for kaempferol-3-rutinoside? |
| A: Safety information for kaempferol-3-rutinoside: 22-45. |
| Q: What is the molecular formula of kaempferol-3-rutinoside? |
| A: Molecular formula of kaempferol-3-rutinoside is C27H30O15. |
| Q: What is the molecular weight of kaempferol-3-rutinoside? |
| A: Molecular weight of kaempferol-3-rutinoside is 594.518. |
| Q: What are the storage conditions for kaempferol-3-rutinoside? |
| A: Storage conditions for kaempferol-3-rutinoside: ?20°C. |
| Q: What is the CAS number of kaempferol-3-rutinoside? |
| A: CAS number of kaempferol-3-rutinoside is 17650-84-9. |
| Q: What is the polar surface area (PSA) of kaempferol-3-rutinoside? |
| A: Polar surface area (PSA) of kaempferol-3-rutinoside is 249.20000. |
| Q: What is the LogP of kaempferol-3-rutinoside? |
| A: LogP of kaempferol-3-rutinoside is 1.96. |
| Q: What are the uses of kaempferol-3-rutinoside? |
| A: Main uses of kaempferol-3-rutinoside: Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Flos Carthami. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |