BMS-193884

Modify Date: 2024-02-28 17:24:59

BMS-193884 structure	Common Name	BMS-193884
	CAS Number	176960-47-7	Molecular Weight	395.43200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₇N₃O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BMS-193884

BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].

Name	N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-2-yl)phenyl]benzenesulfonamide

Description	BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETA:1.4 nM (Ki) ETB:18700 nM (Ki)
References	[1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137.

Molecular Formula	C₂₀H₁₇N₃O₄S
Molecular Weight	395.43200
Exact Mass	395.09400
PSA	106.61000
LogP	5.56800

N-(3,4-dimethyl...

CAS#:176961-14-1

~53%

BMS-193884

CAS#:176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

4-Bromobenzoyl ...

CAS#:586-75-4

BMS-193884

CAS#:176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

Benzamide, 4-bromo-

CAS#:698-67-9

BMS-193884

CAS#:176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

2-(4-Bromopheny...

CAS#:176961-50-5

BMS-193884

CAS#:176960-47-7

Literature: Journal of Medicinal Chemistry, , vol. 43, # 16 p. 3111 - 3117

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

BMS-193884

Use of BMS-193884

Names

BMS-193884 Biological Activity

Chemical & Physical Properties

Synthetic Route

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.