Nicotinic acid riboside

Modify Date: 2024-01-10 21:14:00

Nicotinic acid riboside Structure
Nicotinic acid riboside structure
Common Name Nicotinic acid riboside
CAS Number 17720-18-2 Molecular Weight 255.22
Density N/A Boiling Point N/A
Molecular Formula C11H13NO6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nicotinic acid riboside


Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2].

 Names

Name NARH-oxidized form
Synonym More Synonyms

 Nicotinic acid riboside Biological Activity

Description Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism[1][2].
Related Catalog
In Vitro Nicotinic acid riboside (HepG2 cells; 0.01 nM~0.1 mM) helps FK866-treated cells to maintain viability at low micromolar concentrations[1]. .Nicotinic acid riboside formation and release are caused by overexpression of FLAG-tagged CN-II and CN-III in HEK293 and HepG2 cells. CN-II and CN-III generate Nicotinic acid riboside in vitro by dephosphorylation of nicotinic acid mononucleotide (NAMN)[1].
References

[1]. Sasaki Y, et al. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol. 2021;345:113842.

[2]. Bogan KL, et al. Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside [published correction appears in J Biol Chem. 2010 Jan 29;285(5):3524]. J Biol Chem. 2009;284(50):34861-34869.

 Chemical & Physical Properties

Molecular Formula C11H13NO6
Molecular Weight 255.22
Exact Mass 255.07400
PSA 113.93000

 Synonyms

Nicotinic Acid Riboside
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